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Other GU effects reported in 0.1% to 1% of patients during clinical trials of topiramate as monotherapy or adjunct therapy for epilepsy included urinary retention, renal pain, albuminuria, polyuria, and oliguria

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Class A β-lactamases are serine-dependent enzymes that primarily hydrolyze penicillins and extended-spectrum cephalosporins and are widely disseminated via plasmids [84–91]