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Frontiers | Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models
In TB, AA-derived eicosanoids like prostaglandin E2 (PGE2) and lipoxin A4 (LXA4) regulate MΦ death modalities: PGE2 promotes apoptosis (limiting bacterial spread), whereas LXA4 induces necrosis (facilitating Mtb dissemination) (206–209)
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