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For example, the mechanistic target of rapamycin complexes 2 (mTORC2), which phosphorylates and activates AKT, is required in adipose tissue for ChREBPb expression and for expression of the entire DNL pathway (Figure 1A) (80)
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A number of epitopes from structural and nonstructural viral proteins conserved across a curated subset of β-coronaviruses (human and animal [100]) have been combined into an antigen for delivery in an adeno-associated viral vector that has shown pan-SARS-CoV-2 variant protection in mice [151]
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