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Treatment with a HIF-1α inhibitor (30 μM) or 2-deoxyglucose (2-DG, 8 mM) completely reverses the PTGES-induced increase in alpha-smooth muscle actin (α-SMA) expression—confirming that glycolysis constitutes an essential step in myofibroblast differentiation (32)
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It can react with H 2 O 2 through the enzyme glutathione peroxidase to form water and the oxidized disulfide form of GSH, GSSG
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