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Mechanism of Action Lasix inhibits the NaβΊ/KβΊ/2Clβ» (NKCC2) co-transporter in the thick ascending limb, leading to: β’ Increased excretion of: β’ Sodium (NaβΊ) β’ Potassium (KβΊ) β’ Chloride (Clβ») β’ Water β’ Calcium and magnesium β’ Decreased blood volume and blood pressure β 3
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