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Given copper accumulation risk with prolonged high-dose use, many research protocols use cycles of 4-8 weeks with a break

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discovered that increasing SOD activity significantly lowers the incidence of kidney stone formation and kidney injury, highlighting SOD’s ability to inhibit autophagy and endoplasmic stress response (46).The process of kidney stone formation is highly intricate, such as mitochondrial dysfunction, which disrupts energy metabolism, intracellular calcium ion balance, and the antioxidative defense system, and can lead to tubular cell damage, apoptosis, and the formation of stones through the combination of cellular inclusions and mitochondrial debris with calcium oxalate crystals in the tubular lumen (47)