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Another mechanism of DNA damage caused by R-loops may be mediated by base-excision repair (BER), such as the recruitment of nucleotide excision repair factors RAD1/XPG and RAD2/XPF by R-loop aggregation (Su and Freudenreich, 2017

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It has been shown that alveolar epithelial lining fluid of patients with ARDS is deficient in total GSH compared to normal subjects (107), and neutrophil-mediated oxidants release leads to GSH deficiency and lung cell injury (107)

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