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The latter, tungtungmadic acid, diminished the generation of ROS in tert-butyl hydroperoxide-induced Hepa1c1c7 liver cells, inhibited the activation of caspase-3 (a significant protein of the execution phase of cell apoptosis), and up-regulated heme oxygenase-1 expression, an enzyme with potent antioxidant and anti-inflammatory activities [21]
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