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For example, calcium deficiency has been reported as possibly associated with an increased risk of colorectal or breast cancer ( The relationship between vitamin and mineral supplementation and cancer is still a highly debated topic, considering the widespread use of various supplements and the often-conflicting results reported in the literature ( In this review, we comprehensively discuss the biology and physiology of vitamins and minerals with a specific focus on cancer (Tables 1–4), aiming to highlight their potential role in cancer prevention based on the available evidence, while also emphasizing the importance of addressing deficiencies during oncologic treatment by providing a practical overview to facilitate their recognition and management