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Let’s break down the research behind the best ones: Lactococcus ferment lysate Research from 2023 suggests that adding fermented cultures of various probiotic strains to lotion can improve skin barrier function, reduce skin redness and irritation, and boost moisturization in part by helping to prevent TEWL.29 Matrixyl 3000 and Matrixyl synthe'6 According to a 2023 review, in a small study on 24 men, the use of Matrixyl 3000 for two months led to a reduction in wrinkle depth by 10.2% and wrinkle volume by 17.1%.30 Similarly, another small study using a product that included Matrixyl 3000 as an ingredient (among others) found that, by day 28 of use, 75% of 32 total subjects expressed overall satisfaction with their skin appearance, and the researchers noted a “significant decrease” in the number, depth, and volume of wrinkles.30 While it’s difficult to find research specifically on Matrixyl synthe'6, studies on its active ingredient, palmitoyl tripeptide‐38, suggest that it stimulates the synthesis of collagen and hyaluronic acid, as well as of proteins for wound healing and maintaining the structure of bodily tissues