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Fisetin decreased overall GST activity in cancer cell lines in a dose-dependent manner, which resulted in growth inhibition and apoptosis (programmed cell death) (Youns and Hegazy Reference Youns and Hegazy2017)
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Gastrointestinal conditions significantly impair B12 absorption: Pernicious anaemia , an autoimmune condition affecting intrinsic factor production, requires lifelong intramuscular B12 injections (hydroxocobalamin 1 mg every 2–3 months for maintenance, or every 2 months if neurological involvement) as oral absorption is severely compromised
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