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Notably, a propargyl group at P1′ or alternatively an extended P1′ side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)
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Mitochondria-targeted small molecule SS31: A potential candidate for the treatment of Alzheimer’s disease
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