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In plants, several metal sensors have been described, mostly nutrient transporters, named “transceptors,” that sense their substrates (Ho et al., 2009
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In certain scenarios (e.g., cancer, dividing stem cells, activated T lymphocytes, endometrial decidualization, and presumably patients receiving prolyl hydroxylase inhibitors to treat anemia), HIF activates this switch and promotes glycolysis despite aerobic conditions (i.e., the Warburg effect) 6,9,10,11,12,13,14,15,16,17,18,19
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