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In the stromal compartment, the expression levels of ten biomarkers, including KEAP1, were similarly associated with the response to NAC (Table 1)

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The authors concluded that the compound “resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated.” That sustained rise in the GH and IGF-1 axis is the reason researchers reach for this stack first, and why it anchors most study designs