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The latter shows greater specificity on the human epidermal growth factor receptor 2 (HER2) than the others, being at the same time the first ADC that could be used on solid tumors [12,18,19]
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Intracellularly, iron undergoes reduction to its ferrous form (Fe² + ) by the reductase six-transmembrane epithelial antigen of prostate 3 (STEAP3) before entering the cytoplasm through divalent metal transporter 1 (DMT1)
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