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Ferrous ion has the effect of mediating ROS production and enzyme activity during lipid peroxidation, which can produce a large number of ROS through the Fenton reaction (Dixon et al., 2012), and it also increase the activity of lipoxygenase (LOX) or EGLN prolyl hydroxylases, which are responsible for lipid peroxidation and oxygen homeostasis (Chen P
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Additionally, cognitive impairment itself may diminish the depth and quality of engagement during motor tasks, potentially undermining the synergistic effects of the combined intervention (Steinberg et al., 2019)
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