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In this context, last year, Wang and co-workers disclosed new GLP-1 conjugates modified with dual fatty acid connected by two γGlu linkers, and having at the C-terminus a hydrophilic polypeptide consisting of 100 amino acids, and including repetitive proline, alanine, and serine (PAS100) residues in a defined order, to improve the aqueous solubility (affected by the dual lipidation) (Wang C

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