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Current Research Limitations and Open Questions Despite the volume of preclinical data available, several critical gaps remain in the BPC-157 research record: The absence of randomized controlled human clinical trials limits translation of preclinical findings Definitive receptor binding identification for BPC-157 has not been fully established Long-term safety and toxicological profiling in chronic dosing models remains incomplete Standardized pharmacokinetic data across species and administration routes is limited Mechanistic overlap between proposed pathways requires further dissection using knockout and receptor-specific models These open questions represent productive directions for future preclinical research