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Ferrostatin-1 potently inhibits the release of high mobility group box protein (HMGB)-1, a classical marker of necroinflammatory response, in cell models and human skin explants after UVB irradiation, thus confirming that ferroptosis is a key element of the necroinflammatory process in keratinocytes
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Additionally, TNF-α stimulated the expression of K16 and K17, whereas SFN suppressed their expression (Fig
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