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First-Pass Metabolism — The Stomach’s Own Alcohol Defence The second mechanism is first-pass metabolism — the partial breakdown of alcohol before it reaches systemic circulation

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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM (Van Haren et al., 2021)