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For example, ethanol-induced ROS and free radicals can suppress methionine synthase (MS) activity to inhibit remethylation and induce hyperhomocysteinemia ( via chelation, and it can be used by hepatocytes for GSH synthesis ( via the irreversible transsulfuration pathway, and cysteine then forms either taurine via cysteine dioxygenase (CDO) or GSH via γ-glutamylcysteine synthetase ( Few studies indicated antioxidant enzymes, such as SOD 2 and glutathione S-transferases (GST), were changed after betaine treatment, but most results have shown no significant changes
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