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[DOI] [PubMed] [Google Scholar] 121.Huttunen KM, et al
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Although αSyn wild-type ( WT ) has a hydrophobic (NAC) core, it is shielded by long-range intramolecular interactions, rendering it “inert.” In contrast, Parkinson’s disease (PD)-specific αSyn variants—S129 phosphorylation and C-terminal truncations—aggregate and phase separate more rapidly, suggesting hydrophobic exposure
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