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Collectively, our de novo designed TYR-based therapeutic strategy established an integrative platform to leverage the catalytic activity of TYR to in situ generate various drugs, thereby overcoming the current treatment challenges for enhanced melanin-associated skin disease therapy
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Interestingly, RIPA-56 and Necrostatin-1 (Nec-1, RIPK1 inhibitor) were confirmed to inhibit necroptosis and improve the inflammatory signaling pathway activated in mice fed high-fat diet (Majdi et al., 2020
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