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Advances in Modeling Approaches for Oral Drug Delivery: Artificial Intelligence, Physiologically-Based Pharmacokinetics, and First-Principles Models

Contemporary data from the International Coalition of Medicines Regulatory Authorities (ICMRA) demonstrate that the average time to develop regulatory expertise in emerging therapeutic areas ranges from 5 to 8 years per specialist, with recruitment and retention costs averaging USD 150,000 to USD 300,000 per expert annually in developing-country contexts [20,21]

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Note The author thanks James Batley for CDF data from the Solomon Islands

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