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Clinical Information Pernicious anemia is a complex condition stemming from a vitamin B12 deficiency, essential for making red blood cells and maintaining a healthy nervous system

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Presuming that the putative high-folate–low-vitamin B-12 interaction on serum holoTC and the metabolic markers of vitamin B-12 status is due to excess folic acid, an important consideration is at what level of exposure might these effects become metabolically and clinically relevant

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