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Mechanism 4: the glutamate Transporter-GSH feedback loop A critical mechanistic node integrating the preceding mechanisms is the bidirectional regulation between astrocytic glutamate transporters, principally EAAT2 and the GSH redox system
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The methionine overload would tend to decrease basal hyperhomocysteinemia rather than cause a further increase in basal hyperhomocysteinemia in patients bearing remethylation defects such as folate deficiency (associated or not with the C677T mutation of the MTHFR gene) (Durand et al, 1997a
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