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Peptides vs TRT, Side by Side Mechanism Replaces testosterone directly Stimulates the body’s own hormones or repair systems Primary target Androgen receptors Pituitary, GH axis, tissue receptors Clinical goal Restore testosterone levels Support GH axis, recovery, body composition Best candidate Confirmed low testosterone Normal testosterone with suboptimal GH or recovery Key advantage Fast, predictable, well studied Leaves the natural regulatory axis intact Key limitation Suppresses own production, affects fertility Evidence varies widely, most compounds not FDA approved Evidence level Strong, multiple large RCTs From FDA approved down to preclinical only Regulatory status FDA-approved testosterone products exist for specified indications