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TLR3 can recognize viral double-stranded RNA (dsRNA) and synthetic dsRNA Poly(I:C) or Poly(A:U), while TLR4 is activated by lipopolysaccharides (LPS) from Gram-negative enterobacteria, mannan from Saccharomyces cerevisiae and Candida albicans , and glucuronoxylomannan from Cryptococcus neoformans [138]
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