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The dysregulation and polarization of M1/M2 macrophages can lead to chronic inflammation, infection, cancer, obesity, and their associated disorders such as NAFLD [26]
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Collectively, these advances represent a substantial technical advance in overcoming the long-standing challenges of structural localization and dynamic elimination for extracellular targets, thereby transforming the vast extracellular immunomodulatory proteome into a repertoire of actionable therapeutic targets
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